An autologous transplant is stem cell transplant (ASCT) that uses your own stem cells, which means you are your own donor. In this type of transplant, your stem cells are harvested (removed), frozen and stored before you receive high doses of radiation therapy or chemotherapy, or both.
After you receive your high-dose cancer treatment to remove cancerous cells from your body and/or marrow, your harvested stem cells are thawed and returned back into you. This is known as a “rescue” in autologous transplant.
An autologous transplant uses your own stem cells for transplantation. In contrast, an allogeneic stem cell transplant uses cells from another donor. The donor stem cells must have a genetic typing that matches yours. Usually, donors come from a direct relation (such as a sibling).
Autologous transplant is a type of stem cell transplant used to treat:
Your doctor may recommend an autologous stem cells transplant if your disease will benefit from one as part of your treatment.
Since you are getting your own cells, there is no risk that your immune system will reject the transplant or that the transplanted cells will attack your own body.
A disadvantage of an autologous transplant is the side effects of high dose chemotherapy such as hair loss, nausea, vomiting, diarrhoea, ulcer in the mouth and infection due to low white cells count.
The disadvantage of an autologous transplant is that cancer cells may be harvested along with the stem cells and then reinfused back into the body. To minimise risk, doctors may treat the cells first with anti-cancer drugs or other therapies to reduce the number of cancerous cells that may be present.
You may be ineligible for an autologous stem cell transplant if you have other major health problems such as serious heart, lung, liver, or kidney disease.
Cancer cells may be harvested along with the stem cells and then reinfused back into the body. To minimise risk, your doctor may treat the cells first with anti-cancer drugs or other therapies to reduce the number of cancerous cells that may be present.
Initial side effects can include:
Longer-term side effects can include:
At Parkway East Hospital, our team of medical oncologists and nursing professionals are here to help with the diagnosis and treatment of cancer. Conveniently located in the east of Singapore, we provide holistic and customised treatment in a caring environment to support each patient on their road to recovery.